Project Final Report-08121-2902-04-Bacterial fouling leads to serious problems within the oil and gas industry. Microbiologically influenced corrosion (MIC) affects every step of the system, from the production wellhead to the refinery. Bacterially-evolved hydrogen sulfide sours the reservoir, elevating risk and devaluating the product. Bacterial iron sulfide production creates black powder accumulation, causing gas pipeline blockages. Long deepwater pipelines are particularly at risk and costly biocide injection and regular pig runs increase operating expense and downtime. The petroleum industry currently uses chemical biocides to combat bacteria despite the fact that such biocides are only moderately effective. Moreover, such broad-spectrum chemical biocides are harmful to humans and the environment, and are expensive. A new approach to bacterial control is clearly required. We propose to evaluate the use of bacteriophage, or phage, the natural viral predators of bacteria, in a focused approach to reduce the agents of MIC.