There is significant concern regarding the potential impact of discharges of saline-sodic water from coal bed methane development sites within the Powder River Basin onto irrigated acreages of the area. The specific objective of this study was to assess soil chemical and physical responses upon wetting with saline-sodic water. This was accomplished by exposing soil material collected from sites within the Powder River Basin to various combinations of two water qualities and three wetting/irrigation regimes. Water quality treatments consisted of either synthesized Powder River water or synthesized CBM product water. Wetting and irrigation regimes consisted of: 1) a single wetting event, 2) a five-time wet/dry cycle and 3) a five-time wet/dry cycle followed by a single flood (flushing) event with distilled water. Repeated irrigation with saline-sodic water or water with a chemical signature comparable to the CBYI product water used in this study will result in a general increase in the soil salinity and sodicity. It is likely that elevated soil salinity levels will be substantially higher than published thresholds for some irrigated crops. The impact of rainfall on reducing EC and SAR is more predominant when salt concentrations are high, and in coarser-textured soils. Distilled water applications simulating rainfall resulted in a much greater lowering of EC than for SAR. To assess the effects of saline-sodic water on the physical properties of the soil, water content was measured after the soils were exposed to the various water qualities and treatment scenarios at five different pressure potentials. It was found that water content associated with matric potential differed significantly due to predominant soil textures. Although statistically significant differences were detected among water quality treatments, differences were not considered large enough to have a significant ecological impact. It was determined that CBM product water applied at these levels did not have a consistent significant impact on soil physical properties.