Gas Technology Institute (GTI) is advancing the Ohio State University’s (OSU) transformational membrane-based carbon dioxide (CO2) capture technology through engineering-scale testing on actual coal-derived flue gas at the Wyoming Integrated Test Center (ITC). The amine-containing CO2-selective membranes developed under U.S. Department of Energy (DOE)-funded projects (FE0031731; FE0026919; FE0007632) consist of a thin selective layer coated on a polymer support and exhibit high CO2 permeance and very high selectivity of CO2 over nitrogen (N2). The superior performance is based on a facilitated transport mechanism, in which a reversible CO2 reaction with fixed-site and mobile amine carriers enhances the CO2/N2 separation. The objectives of this project are to fabricate commercial-size membrane modules; design and install a 1-megawatt-electric (MWe) CO2 capture system at ITC; conduct parametric testing with one- and two-stage membrane processes at varying CO2 capture rates (60–90%); perform continuous testing at steady-state operation for a minimum of two months; and gather the data necessary for further process scale-up.