Field and laboratory studies were combined to establish relations between the sedimentology and geochemistry of uranium and other metals. Uranium and molybdenum contents of 50-100 ppm occur in Upper Devonian shales in Tennessee and newly identified areas on Kentucky and Indiana. These high values are found in organic-rich sediments and are restricted to certain stratigrapic units and specific parts of the basin. Even higher uranium contents are observed in some phosphate-rich units in Indiana. Other metals such as copper, nickel, ad vanadium also are associated with organic matter in the shale. Pyrite contents of 5-10 percent also are present with arsenic, zinc ad mercury.