This dataset provides a set of polygons representing the zone of depletion for historic submarine landslides (also referred to as mass transport deposits) within four regions of the US Exclusive Economic Zone in the northern Gulf of Mexico. Landslides were digitized by geologists and spatial scientists at the National Energy Technology Laboratory by visually interpreting landslide boundaries from a seismic-derived, high resolution bathymetric hillshade provided by the Bureau of Ocean and Energy Management (BOEM, 2017). A portion of the landslide features are derived from other spatial sources including the Seismic Water Anomalies dataset by BOEM (2016) as well as from McAdoo et al., 2000 and Twichell et al, 2005. The scale that landslides depletion areas can be interpreted at is limited by the spatial resolution of the gridded bathymetry, which is 12.192 meters (BOEM, 2017). For each landslide feature in the dataset, geometry metrics were calculated including geodesic area (km2) and geodesic perimeter (km) using the North America Albers Equal Area Conic projected coordinate system. The same geometry metrics were calculated for the four inventory regions.