This report summarizes the Los Alamos National Laboratory research activities addressing health and environmental concerns related to the developing US oil shale industry for calendar year 1981. Individual projects are carried out by investigators in several groups within the Laboratory's Life Sciences (LS), Health (H), and Chemistry (CHM) Divisions, with support from the Office of Health and Environmental Research and the Assistant Secretary for Fossil Energy of the United States Department of Energy (DOE). The technical reports included in this document are organized on the basis of materials of concern rather than on Laboratory organizational structure. Site- and technology-specific information is included in those instances where it is important to the understanding of the problem. Certain of the projects address more generic or fundamental questions common to most technologies, but each study, whether generic or applied, fits within the health and environmental concerns stated in the DOE Oil Shale Research Development and Demonstration (RD and D) Plan. Separate abstracts have been prepared for each of the 21 technical reports for inclusion in the Energy Data Base.