Pacific Northwest National Laboratory (PNNL) aims to perform molecular refinement of third-generation water-lean solvents during this project. The objectives are to reduce volatility while retaining desirable physical and thermodynamic properties, study the molecular underpinnings of solvent degradation (e.g., hydrolysis, nitration, oxidation), design new molecules that are resistant to these chemical degradations, and decrease infrastructure capital expenditures (CAPEX) while increasing longevity by replacing steel with cheaper and more durable plastics. This proposal builds on PNNL’s integrated solvent development approach, with an integrated effort combining the elements of computation, advanced synthesis and testing capabilities, and comprehensive material property testing to refine advanced solvent performance while also reducing the CAPEX of these third-generation solvents.