The objective of this research is to use molecular modeling techniques, coupled with our prior experimental results, to design, synthesize and evaluate inexpensive, non-fluorous carbon dioxide thickening agents. The first type of thickener to be considered is associating polymers. Typically, these thickeners are copolymers that contain a highly CO2-philic monomer, and a small concentration of a CO2-phobic associating monomer. Yale University will be solely responsible for the synthesis of a second type of thickener; small, hydrogen bonding compounds. These molecules have a core that contains one or more hydrogen-bonding groups, such as urea or amide groups. Non-fluorous, CO2-philic functional groups will be attached to the hydrogen bonding core of the compound to impart CO2 stability and macromolecular stability to the linear ?stack? of these compounds. The third type of compound under investigation is CO2-soluble surfactants. These surfactants contain conventional ionic head groups and composed of CO2-philic oligomers (short polymers) or small compounds (sugar acetates) previously identified by our research team. Mobility reduction could occur as these surfactant solutions contacted reservoir brine during CO2 injection, or via the self-assembly of surfactants into viscosity enhancing cylindrical micelles. This report thoroughly documents the synthesis and characterization of the first series of nonfluorous, ionic, highly CO2-soluble surfactants that has been reported. Specific tails include oligo(vinyl acetate), sugar acetates, and oligo(propylene oxide). The surfactants with vinyl acetate tails were particularly promising. The report also includes preliminary foam stability test results conducted in a high pressure view cell. Several of the surfactants, most notably those with oligomeric vinyl acetate tails, yielded the most stable foams. Our subsequent work will investigate the ability of these surfactant solutions to generate stable foams in a brine-saturated sandstone core with our colleague Reid Grigg at New Mexico Tech PRRC.