"A continuous, wet-wick, thermistor-type, differential vapor pressure detector was studied for use in liquid elution chromatography. When thermistors matched to 14-ppm resistance per degree were used, the observed detection limit was 0.8 X 10- 1 mole kg - 1 with cyclohexane solvent. The effective sensing volume of the detector was 90 uL at a flow rate of 2.0 ml/hour decreasing at lower flow rates. An alkane-alkene type analysis on a shale-oil middle distillate is demonstrated on a small silica gel column. A post -column stream splitter to increase system throughput is described. Available resolution is presented for typical, 0.Z54-cm i.d., adsorbent-packed columns of various lengths. The resolution was evaluated for columns operated with O.2-cm HETP in the presence of a 90-uL detector-volume effect relative to the zero extra-column volume case. The observable resolution with detector broadening for a 4-m column is 90% of the available for bands eluting in 3 column-void volumes. The capability of this type of small-column system is compared with the capability of TLC. The small column system can generate as much resolution as a TLC system in appreciably less time."